Table 2.

Genotype and allele frequencies of functional genetic variants at the FCGR2/3 locus, comparing KD patients of European descent with healthy controls of European descent.

Variant	Cases	Controls	Fisher	Single logistic regression (additive model)		Multiple logistic regression
	(n = 405)	(n = 919)				All variants	2 variants
			P-value	OR (95%LL-95%UL)	P-value	P-value	P-value
CNR1
(FCGR2C + FCGR3B)
0 copies	1	1		<2 vs. rest:
1 copy	27	60		1.04 (0.66–1.66)	0.853	0.719
2 copies	348	768
3 copies	27	83		>2 vs. rest:
4 copies	2	7	0.533	0.71 (0.46–1.10)	0.124	0.291
CNR2
(FCGR2C + FCGR3A)
1 copy	3	11		<2 vs. rest:
2 copies	376	866		0.62 (0.17–2.22)	0.459	0.491
3 copies	25	41		>2 vs. rest:
4 copies	1	1	0.390	1.43 (0.87–2.37)	0.162	0.256
CNR3
(FCGR2C + FCGR3A)
2 copies	405	917		>2 vs. rest:
3 copies	0	2	1.000	0.00 (0.00-inf)	0.973	0.973
FCGR2A Q27W
QQ	289	713
QW	108	194
WW	8	12	0.047
Allele frequency (W)	15.3%	11.9%		1.35 (1.06–1.72)	0.014	0.783
FCGR2A H131R
HH	122	269
HR	211	463
RR	72	187	0.559
Allele frequency (H)	56.2%	54.5%		1.07 (0.91–1.27)	0.408	0.857	0.927
FCGR3A V158F
0 V (F, FF, FFF, FFFF)	150	386
1 V (V, VF, VFF)	205	403
2 V (VV, VVF, VVFF)	47	128
3 V (VVV)	3	2	0.046
Allele frequency (V)	37.0%	35.5%		1.08 (0.91–1.28)	0.373	0.606
FCGR2C promoter
0 2B.2	286	717
1 2B.2	110	185
2 2B.2	9	16
3 2B.2	0	1	0.017
Allele frequency (2B.2)	15.3%	11.5%		1.37 (1.08–1.72)	0.009	NE
FCGR2C
ORF/Stop/NC-ORF
0 ORF	283	721
1 ORF	113	184
2 ORF	9	13
3 ORF	0	1	0.005
0 NC-ORF	389	853
1 NC-ORF	6	33
2 NC-ORF	10	33	0.059
Allele frequency (ORF)	15.7%	11.2%		1.46 (1.16–1.85)	0.002	0.093	0.002
Allele frequency (NC-ORF)	3.1%	5.2%		0.72 (0.51–1.02)	0.063	0.112
Allele frequency (Stop)	81.2%	83.7%		0.88 (0.74–1.04)	0.136
FCGR3B NA1/NA2/SH
0 NA1	158	373
1 NA1	201	430
2 NA1	45	114
3 NA1	1	2	0.754
0 SH	389	874
1 SH	16	45	0.481
Allele frequency (NA1)	36.2%	35.3%		1.01 (0.85–1.20)	0.933	0.537
Allele frequency (NA2)	63.8%	64.7%		0.94 (0.80–1.12)
Allele frequency (SH)	4.0%	4.9%		0.80 (0.45–1.43)	0.450	0.247
FCGR2B promoter
0 2B.4	307	748
1 2B.4	93	157
2 2B.4	5	14	0.043
Allele frequency (2B.4)	12.7%	10.0%		1.29 (1.00–1.67)	0.047	0.834
FCGR2B I232T
II	322	697
IT	76	201
TT	7	21	0.359
Allele frequency (T)	11.1%	13.2%		0.83 (0.64–1.06)	0.141	0.189

For SNPs that are subject to CNV, several genotypes are pooled as indicated to combine all the different genotypes with the same copy number of 1 of the variants. For the tri-allelic haplotypes in FCGR2C and FCGR3B, this is done for two of the haplotypes separately. Fisher exact test was calculated on genotype frequencies as shown in the table. A single logistic regression analysis was performed for each (presumed) risk allele in an additive model. A multiple logistic regression analysis was performed on all variants (except the FCGR2C promoter haplotypes, which were left out of the multiple logistic regression analysis because of the near perfect LD with the classic FCGR2C-ORF haplotype) and on FCGR2A-H131R and classic FCGR2C-ORF alone. P-values < 0.05 are shown in bold.