Table 3.
Transmission disequilibrium test for the different variants at the FCGR2/3 locus in a family-based association study.
| Allele/haplotype (on 1 chromosome) | Allele frequency | # families* | Z | P-value |
|---|---|---|---|---|
| CNR1 | ||||
| 0 (deletion) | 0.049 | 105 | 0.285 | 0.776 |
| 1 | 0.875 | 214 | −0.065 | 0.948 |
| 2 (duplication) | 0.074 | 133 | −0.338 | 0.735 |
| CNR2 | ||||
| 0 (deletion) | 0.006 | 13 | −0.277 | 0.782 |
| 1 | 0.976 | 61 | 0.378 | 0.705 |
| 2 (duplication) | 0.018 | 48 | −0.429 | 0.668 |
| FCGR2A Q27W | ||||
| Q | 0.891 | 210 | −0.328 | 0.743 |
| W | 0.109 | 210 | 0.328 | 0.743 |
| FCGR2A H131R | ||||
| H | 0.575 | 431 | 2.750 | 0.006 |
| R | 0.425 | 431 | −2.750 | 0.006 |
| FCGR3A V158F | ||||
| – | 0.005 | 11 | −0.302 | 0.763 |
| F | 0.642 | 395 | 0.483 | 0.629 |
| FF | 0.010 | 27 | 0.577 | 0.564 |
| VF | 0.006 | 18 | −2.828 | 0.005 |
| V | 0.331 | 397 | −0.088 | 0.930 |
| VV | 0.004 | 10 | 0 | 1.000 |
| Promoter FCGR2C | ||||
| - | 0.055 | 114 | 0.451 | 0.652 |
| 2B.1 | 0.748 | 349 | −0.242 | 0.809 |
| 2B.1-2B.1 | 0.089 | 164 | −0.818 | 0.414 |
| 2B.2 | 0.099 | 182 | 0.491 | 0.623 |
| FCGR2C ORF/Stop/NC-ORF** | ||||
| – | 0.055 | 115 | 0.268 | 0.788 |
| ORF | 0.100 | 184 | 1.120 | 0.263 |
| Stop | 0.743 | 354 | −0.241 | 0.810 |
| NC-ORF | 0.009 | 23 | −1.460 | 0.144 |
| Stop-stop | 0.075 | 143 | −0.477 | 0.633 |
| NC-ORF-NC-ORF | 0.007 | 19 | −0.229 | 0.819 |
| FCGR3B NA1/NA2/SH | ||||
| – | 0.053 | 108 | 0.186 | 0.853 |
| NA1 | 0.362 | 389 | 0.490 | 0.624 |
| NA1-NA2 | 0.051 | 96 | −0.198 | 0.843 |
| NA1-SH | 0.009 | 21 | 0.218 | 0.827 |
| NA2 | 0.508 | 396 | −0.439 | 0.660 |
| NA2-NA2 | 0.004 | 11 | −0.905 | 0.366 |
| SH | 0.004 | 12 | −1.155 | 0.248 |
| Promoter FCGR2B | ||||
| 2B.1 | 0.905 | 185 | −0.563 | 0.574 |
| 2B.4 | 0.090 | 172 | 0.946 | 0.344 |
| FCGR2B I232T | ||||
| I | 0.867 | 226 | 0.741 | 0.459 |
| T | 0.133 | 226 | −0.741 | 0.459 |
*
Number of informative families (i.e., at least one of the parents is heterozygous for the indicated allele or haplotype). Only alleles for which the number of informative families is >10 are shown.
**
ORF means classic FCGR2C-ORF haplotype, NC-ORF means nonclassic FCGR2C-ORF haplotype. Z; Z statistic, a positive Z indicates more transmission than expected, a negative Z indicates less transmission than expected, P indicates whether Z is significantly different from 0, P < 0.05 is considered significant.