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The GPR139 agonist (10 mg/kg, p.o.) produced a significant decrease in time spent sniffing the rewarding mouse female urine cue, but had no effect on time spent sniffing the control cue (A). In mouse tail suspension (B), imipramine (3–10 mg/kg, i.p.) decreased immobility time as expected, but there were no significant effects of the GPR139 agonist (10 mg/kg, p.o.).
