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. 2019 Mar 21;13:108. doi: 10.3389/fncel.2019.00108

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Copyright © 2019 Li, Li, Fan, Wang, Li, Wen, Deng, Tan, Pan, Hu, Zhang, Lai and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AA inhibits the M1 polarization of macrophages but promotes M2 polarization in vivo. (A–F) Representative images of f4/80 (red) and iNOS (green) double immunohistochemistry in each group. (G–L) Representative images of f4/80 (red) and CD163 (green) double immunohistochemistry in each group. (M) The ratio of iNOS/f4/80 in each group (n = 3, *P < 0.05). (N) The ratio of CD163/f4/80 in each group (n = 3, *P < 0.05). (O–Q) Western blots and schematic diagrams of the statistical analysis showing the protein levels of iNOS and CD163 in the distal trunk of the injured sciatic nerves (n = 3, *P < 0.05).