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. 2019 Mar 27;9:5282. doi: 10.1038/s41598-019-41503-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pattern separation assay in acute brain slices at the single cell level. (a) Examples of input sets. Top: each input set comprises five different trains of electrical pulses. Bottom: correlation coefficient matrix for each input set, each square representing the correlation coefficient between two input trains measured with a binning window (τ_w) of 10 ms. R_input is the average of coefficients, diagonal excluded. (b) Histology of the DG in a horizontal slice (Cresyl violet/Nissl staining; scale bar: 250 µm), overlaid with a schematic of the experimental setup: a theta pipette in the ML (input) is used to focally stimulate the PP while a responding GC (output) is recorded via whole-cell patch-clamp. (GCL: granule cell layer, H: hilus, ML: molecular layer, FS: fast-spiking interneuron. Solid lines represent dendrites and dashed lines axons). (c) Current-clamp recordings of the membrane potential of two different GCs in response to different input sets (Top: R_input = 1; Bottom: R_input = 0.76). Each input set (five input traces) is repeated ten times (only three repetitions are shown, with spikes truncated at 0 mV). In the bottom graph, input trains and their respective children output spiketrains have matching colors.