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. 2019 Mar 27;9:5276. doi: 10.1038/s41598-019-40888-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Visualizing the spatial heterogeneity of whole-tumor hemodynamics and intravascular oxygenation. 3D visualizations of hemodynamic heterogeneity in microvascular networks derived from (a–c) Day 21 tumors and (d–h) Day 35 tumors wherein the vessels are color coded by their simulated blood flow rates, Q × 10⁻⁷ (ml/s) (in top row) and intravascular oxygenation, PO₂ values (mm Hg) (in bottom row). (i) Pooled frequency distributions of simulated Q (top row) and PO₂ (bottom row) for all vessels of Day 21 tumors (light grey) and Day 35 tumors (dark grey).