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. 2019 Mar 27;9:5273. doi: 10.1038/s41598-019-41654-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MAP-2 expression in young, aged and LM11A-31 treated/aged mice. The MAP-2 was imaged to eliminate background signal and provide a clean MAP-2 signal. The values shown therefore reflect relative MAP-2 intensities but not absolute expression. A significant loss of MAP-2 signal is observed in aged mice, which is partially recovered with LM11A-31 treatment, significantly in the CA1 and CA3 regions. ***P < 0.001 for comparison with young animals, other P values as indicated; N = 6 animals/group; ANOVA with post-hoc Student-Newman-Keuls testing.