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. 2019 Mar 27;9:5273. doi: 10.1038/s41598-019-41654-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Western blot analysis of synaptophysin levels in the hippocampus of 4-month-old mice and 25-month-old mice treated with 50 mg/kg LM11A-31 or vehicle (saline) from 21 to 25 months. (A) In the hippocampus and cortex, synaptophysin was reduced in aged mice relative to young mice and partially restored by treatment with LM11A-31. The bands shown are representative of the differences seen across nine different blots and were acquired from the gel scans in Supplemental Fig. S1. Beta actin bands were generated from the same blot after stripping and re-probing. (B) Synaptophysin signal normalized to beta-actin showed significant age-related reduction in hippocampus, cortex and striatum with a significant recovery of signal associated with LM11A-31 treatment in the hippocampus and cortex (p’s = 0.005–0.014, t test, treated vs vehicle, n = 9). Values are mean + sem. a, P < 0.001 relative to young mice.