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. 2019 Mar 27;10:1388. doi: 10.1038/s41467-019-09374-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Fusion identification in clinical cohort samples. a FISH identification of ROS1 rearrangement in lung cancer sample MO-16-000393. Positive signal is 1 fused set of red and green dots and ≥1 isolated green dots per cell. White arrows point to fused dots; grey arrows point to green dots. b FISH identification of ALK rearrangement in lung cancer sample SP-15-11000. Positive signal is 1 fused set of red and green dots, 1 isolated red and 1 isolated green dot per cell. White arrows point to fused dots; grey arrows point to isolated red and green dots. c RT-PCR analysis to diagnose TMPRSS2-ERG fusion genes in prostate samples. * indicates TMPRSS2-ERG bands. Source data are provided as a Source Data file. d Overview of fusion gene identification in all clinical cohort samples; each oval represents one patient. Other blood cancers includes chronic lymphocytic leukaemia, multiple myeloma and uncategorised blood cancer patients. BMA=bone marrow aspirate; PB=peripheral blood; FFPE=formalin-fixed paraffin-embedded. e Read coverage across EZR and ROS1 genes in lung cancer patient sample MO-16-000393. Dotted line marks fusion junction of EZR-ROS1 fusion gene