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. 2019 Mar 27;9:5280. doi: 10.1038/s41598-019-41747-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characteristics of disease outcomes in G93A mice receiving hBMEPCs at symptomatic stage. Transplanted ALS mice with cell dose of 1 × 10⁶ at 4 weeks post-treatment (A) significantly maintained body weight, (B) better extended hindlimbs, (C) delayed loss in muscle strength, and (D) stayed longer on rotarod vs. media-injected mice. Notable beneficial effects on motor function were determined in G93A mice 2–3 weeks after cell transplantation. ^*p < 0.05, ^**p < 0.01.