Table 3.
Changes in glycaemic variability profiles for MAGE, CONGA-1, 2, 4 and 8 during the study and comparisons between treatments
| Variable | RT-CGM (n = 9) | Blinded CGM (n = 6) | P value (ANCOVA) | ||||
|---|---|---|---|---|---|---|---|
| Baseline | 12 weeks | Change | Baseline | 12 weeks | Change | ||
| CONGA-1 (mmol/L) | 1.30 ± 0.36 | 1.03 ± 0.36 | − 0.27 ± 0.36 | 1.24 ± 0.41 | 1.30 ± 0.48 | 0.06 ± 0.19 | 0.074 |
| CONGA-2 (mmol/L) | 1.72 ± 0.51 | 1.36 ± 0.55 | − 0.36 ± 0.54 | 1.79 ± 0.633 | 1.84 ± 0.77 | 0.05 ± 2.88 | 0.110 |
| CONGA-4 (mmol/L) | 2.02 ± 0.68 | 1.58 ± 0.75 | − 0.44 ± 0.67 | 2.18 ± 0.74 | 2.16 ± 0.93 | − 0.02 ± 0.42 | 0.186 |
| CONGA-8 (mmol/L) | 2.09 ± 0.68 | 1.73 ± 0.83 | − 0.36 ± 0.61 | 2.25 ± 0.73 | 2.22 ± 0.95 | − 0.02 ± 0.52 | 0.298 |
| MAGE (mmol/L) | 3.69 ± 1.08 | 3.01 ± 1.44 | − 0.69 ± 1.14 | 4.06 ± 1.23 | 4.05 ± 1.61 | − 0.09 ± 0.80 | 0.250 |
Total analysed n = 15 (RT-CGM 9, blinded CGM 6). Missing glucose data due to device recording or sensor insertion error. All values are mean ± SD unless otherwise stated
RT-CGM real-time continuous glucose monitoring, Blinded CGM blinded continuous glucose monitoring, CONGA-1 continuous overall net glycaemic action of observations 1 h apart, CONGA-2 continuous overall net glycaemic action of observations 2-h apart, CONGA-4 continuous overall net glycaemic action of observations 4 h apart, CONGA-8 continuous overall net glycaemic action of observations 8 h apart, MAGE mean amplitude of glycaemic excursions