Skip to main content
. 2018 Dec 6;100(3):721–736. doi: 10.1093/biolre/ioy225

Figure 1.

Figure 1.

Schematic of the generation of the two PP1γ isoforms. The Ppp1cc pre-mRNA of approximately 16.91 kb constitutes 5΄ UTR, 3΄ UTR, 8 exons, and 7 introns. The PP1γ1 mature mRNA of approximately 2.3 kb is generated by splicing of introns 1 through 6. Intron 7 is retained in the mature transcript along with exon 8 as a part of its 3΄ UTR. It encodes a protein containing 303 amino acids derived from the 7 exons and 8 amino acids from the extended exon 7 (i.e. initial part of intron 7). In the male meiotic and postmeiotic germ cells, the introns 1–6 along with the 1.1-kb long intron 7 are spliced out, thus producing a shorter PP1γ2 transcript of approximately 1.7 kb. The exon 8 gives PP1γ2 its unique 22 amino acid C-terminus. PP1γ1 and PP1γ2 proteins are identical in structure and their catalytic domain except for the extra C-terminus tail in PP1γ2.