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MIC after mutant selection of E. coli MG1655 (MP100) expressing OXA-48 (MP101) toward CAZ (MP102) and CAZ-AVI (MP103)a
| Strain | MIC (mg/liter)b
|
|
|---|---|---|
| CAZ | CAZ-AVI | |
| MP100 | 0.25 | 0.12 |
| MP101 | 0.25 | 0.12 |
| MP102 | 32 | 2 |
| MP103 | 32 | 16 |
Mutants were selected by a two-step selection procedure on plates. Tests were performed in duplicates.
CAZ, ceftazidime; CAZ-AVI, ceftazidime-avibactam with avibactam fixed at 4 µg/ml.
