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IC50s of tazobactam and avibactam against OXA-48, OXA-48:P68A, and OXA-48:P68A,Y211S
| Antimicrobial agent |
IC50 (µM) fora
: |
||
|---|---|---|---|
| OXA-48 | OXA-48:P68A | OXA-48:P68A,Y211S | |
| Tazobactam | 95 ± 9 | 4 ± 1 | 31 ± 5 |
| Avibactam | 2.2 ± 0.6 | 1.3 ± 0.3 | 13 ± 3 |
IC50s (50% inhibitory concentrations) were determined using nitrocefin as a reporter substrate. Enzymes and inhibitor were incubated together for 5 min. Errors are displayed as 95% confidence intervals.
