TABLE 6.
MIC after transformation of E. coli MG1655 with the native and adapted plasmids
| Antimicrobial agenta |
MIC (mg/liter)b
|
|||
|---|---|---|---|---|
| MP100 | MP101 | MP107 | MP108 | |
| Penicillins and inhibitor combinations |
||||
| TRM | 8 | 256 | 128 | 32 |
| TZP | 8 | 128 | 128 | 128 |
| AMC | 2 | 64 | 4 | 4 |
| Cephalosporins | ||||
| CAZ | 0.25 | 0.25 | 16 | 32 |
| CAZ-AVI | 0.12 | 0.12 | 0.25 | 4 |
| CXM | 8 | 16 | 16 | 8 |
| FEP | 0.06 | 0.25 | 0.5 | 0.25 |
| FOT | 0.12 | 0.5 | 1 | 0.25 |
| Carbapenems | ||||
| MEM | 0.03 | 0.25 | 0.06 | 0.06 |
| IMI | 0.12 | 1 | 0.25 | 0.25 |
| ETP | 0.015 | 1 | 0.25 | 0.12 |
| DOR | 0.015 | 0.03 | 0.03 | 0.03 |
a
TRM, temocillin; TZP, piperacillin-tazobactam with tazobactam fixed at 4 µg/ml; AMC, amoxicillin-clavulanic acid with clavulanic acid fixed at 2 µg/ml; CAZ, ceftazidime; CAZ-AVI, ceftazidime-avibactam with avibactam fixed at 4 µg/ml; CXM, cefuroxime; FEP, cefepime; FOT, cefotaxime; MEM, meropenem; IMI, imipenem; ETP, ertapenem; DOR, doripenem.
b
Shown are the MICs after transformation of E. coli MG1655 (MP100) with the native plasmid (MP101) and adapted plasmids p50579417-OXA-48-CAZ (MP107) and p50579417-OXA-48-CAZ-AVI (MP108). Tests were performed in duplicates.