FIG 3.

Male and female mice exhibited similar clinical symptoms during the chronic inflammatory phase of HSV-1 corneal infection. Clinical symptoms were scored for each mouse and recorded each day from inoculation to the chronic inflammatory phase (days 0 to 14). Mice were scored on the severity and presence of lesions (A and B), neurological (Neuro.) disease (C and D), and eye disease (E), as well as on corneal sensitivity (F) and weight loss (not shown). (A) Maximum (Max.) lesion score within 14 dpi. (C) Maximum neurological disease score within 14 dpi. (E) Maximum eye disease score within 14 dpi. (B) Lesion score from 0 to 14 dpi. (D) Neurological disease score from 0 to 14 dpi. (F) Corneal sensitivity from 0 to 14 dpi. n = 5 mice per group, 2 replicates. No difference was observed between the sexes. Scores and sensitivity levels (calculated as means ± SEM) were analyzed using two-tailed t tests with Holm-Sidak's correction for multiple comparisons.