Table 4.
Tolerability and efficacy data comparing patients with large-vessel occlusion according to symptom onset to reperfusion time.
| Symptom onset to reperfusion 0–180 min (n = 192) |
Symptom onset to reperfusion 180–360 min (n = 876) |
Symptom onset to reperfusion >360 min (n = 393) |
p | All patients with available TTR (n = 1461) | |
|---|---|---|---|---|---|
| Efficacy | |||||
| mTICI 3 | 111 (57.8%) | 423 (48.3%) | 152 (38.7%) | <0.001 | 686 (47.0%) |
| mTICI 2b, 2c or 3 | 187 (97.4%) | 774 (88.4%) | 316 (80.4%) | <0.001 | 1277 (87.4%) |
| Time from onset of symptoms to groin puncture (min) | 117 (IQR 94–135) | 205 (IQR 170–245) | 382 (IQR 332–561) | <0.001 | 225 (IQR 162–309) |
| Time from groin puncture to reperfusion (min) | 30 (IQR 21–42) | 47 (IQR 30–75) | 54 (IQR 33–88) | <0.001 | 45 (IQR 30–72) |
| General anaesthesia | 70 (36.5%) | 484 (55.6%) | 225 (57.5%) | <0.001 | 779 (53.6%) |
| Additional intra-arterial thrombolytics | 7 (3.7%) | 90 (10.3%) | 18 (4.6%) | <0.001 | 115 (7.9%) |
| Balloon guiding catheter | 89 (46.4%) | 469 (53.6%) | 223 (56.7%) | 0.061 | 781 (53.5%) |
| Intermediate aspiration catheter | 97 (54.8%) | 405 (50.9%) | 187 (51.7%) | 0.640 | 689 (51.6%) |
| Manoeuvre count | 1 (IQR 1–2) | 1 (IQR 1–2) | 2 (IQR 1–3) | <0.001 | |
| Intracranial stenting | 2 (1.0%) | 19 (2.2%) | 5 (1.3%) | 0.382 | 26 (1.8%) |
| Extracranial stenting | 14 (7.3%) | 92 (10.5%) | 57 (14.5%) | 0.022 | 163 (11.2%) |
| Safety | |||||
| sICH ECASS II definition | 6 (3.1%) | 67 (7.7%) | 21 (5.4%) | 0.040 | 94 (6.5%) |
| Systemic bleeding | 1 (2.1%) | 11 (3.4%) | 0 (0.0%) | 0.098 | 12 (2.4%) |
| Craniectomy | 3 (1.6%) | 29 (3.3%) | 14 (3.6%) | 0.389 | 46 (3.2%) |
| Non-haemorrhagic worsening | 7 (4.2%) | 54 (8.0%) | 27 (9.4%) | 0.138 | 88 (7.8%) |
| Any interventional complication of: | 14 (7.3%) | 118 (13.5%) | 59 (15.0%) | 0.029 | 191 (13.1%) |
| − Vasospasms | 4 (28.6%) | 29 (24.4%) | 17 (27.9%) | 49 (25.7%) | |
| − Cervical dissection | 3 (21.4%) | 28 (23.5%) | 8 (13.1%) | 38 (19.9%) | |
| − Perforation | 2 (14.3%) | 9 (7.6%) | 5 (8.2%) | 16 (8.4%) | |
| − Other | 2 (14.3%) | 16 (13.4%) | 9 (14.8%) | 26 (13.6 %) | |
| − Emboli to new territory | 3 (21.4%) | 37 (31.1%) | 22 (36.1%) | 62 (32.5%) |
TTR: time to reperfusion; LVO, large-vessel occlusion; mTICI, modified treatment in cerebral ischaemia; sICH, symptomatic intracranial haemorrhage according to European Co-operative Acute Stroke Study-II definition.