Table 2.
Summary of magnetic resonance spectroscopy studies evaluating myocardial triglyceride content in T2D.
| Study | Patients | n | Mean age (years) | M/F | Mean BMI (kg/m2) | Key outcomes |
|---|---|---|---|---|---|---|
| McGavock 96 | Lean controls | 15 | 35 ± 3 | 7/8 | 23 ± 2 | Myocardial TG elevated in IGT and T2D versus controls (0.95 ± 0.60 versus 1.06 ± 0.62 versus 0.46 ± 0.30 fat/water, p < 0.05) |
| Obese | 21 | 36 ± 12 | 10/11 | 32 ± 5 | ||
| IGT | 20 | 49 ± 9 | 5/15 | 31 ± 6 | ||
| T2D | 78 | 47 ± 10 | 37/41 | 34 ± 7 | ||
| Rijzewijk et al. 72 | Controls | 28 | 54 ± 1 | 28/0 | 26.9 ± 0.5 | Myocardial TG increased in T2D versus controls (0.96 ± 0.07% versus 0.65 ± 0.05%, p < 0.05) |
| T2D | 38 | 57 ± 1 | 38/0 | 28.1 ± 0.6 | ||
| Korosoglou et al. 74 | Controls | 16 | 62 ± 3 | 10/6 | 23.9 ± 2.5 | Myocardial TG in T2D 0.86 ± 0.14 Association between TG and mean diastolic strain rate (r = −0.71, p < 0.001) and peak systolic strain rate (r = 0.41, p = 0.02) |
| T2D | 42 | 62 ± 6 | 26/16 | 31.6 ± 4.8 | ||
| Levelt et al. 33 | Controls | 20 | 54 ± 10 | 9/11 | 28.6 ± 2.8 | Elevated myocardial TG in T2D (1.13 ± 0.78 versus 0.64 ± 0.52, p = 0.017) Negative correlation between TG and systolic strain (r = −0.40, p = 0.003) |
| T2D | 46 | 55 ± 9 | 24/22 | 29.6 ± 5.7 |
BMI, body mass index; IGT, impaired glucose tolerance; TG, triglyceride; T2D, type 2 diabetes.