Table 2.

Clinical events that occurred during the observation period

Event reported	Early warninga (days)	Time from event to crossingc (days)	Time in alert state (days)	Maximum HeartLogic index value	Sensors with worsening on the day of the alert threshold crossing
					S3	S3/S1	TI	RR	RSBI	NHR
1. HF hospitalization	b	—	54	28	NA	NA	x	x	x	x
2. HF hospitalization	8	—	71	43		x	x
3. HF hospitalizationd	58	—	71	22		x	x
4. HF hospitalization	69	—	70	40	x	x
5. Hospitalization for pleuritis (secondary diagnosis HF)	17	—	61	40	x			x		x
6. Patient‐reported weight gain	28	—	40	18	x	x		x
7. Patient‐reported weight gain	1	—	18	22	x	x				x
8. Patient‐reported weight gain and worsened dyspnoea	15	—	52	38		x				x
9. Patient‐reported fatigue and worsened dyspnoea	1	—	16	19	x	x		x	x
10. Patient‐reported worsened nocturnal dyspnoea	0	—	8	16	x	x		x		x
11. Large increase in BNP measured at scheduled visit	14	—	61	25	x	x	x			x
12. Large increase in BNP measured at scheduled visit	42	—	139	31	x	x	x			x
13. Worsened HF signs at scheduled visit	0	—	46	22	x			x	x	x
14. Worsened HF signs at scheduled visit	20	—	31	39	x	x	x	NA	NA	x
15. Patient‐reported weight gain after reduction of diuretic dose	10	11	31	25	x	x	x			x
16. Reduction of diuretic dose (no symptoms)	—	60	38	20	x	x				x
17. Reduction of diuretic dose (no symptoms)	—	54	15	30	x	x	x	x	x
18. Reduction of diuretic dose (no symptoms)	—	5	24	20	x	x			x
19. Reduction of diuretic dose (no symptoms)	—	20	22	30	x	x	x	x	x
20. Discontinuation of ACE‐inhibitor therapy (no symptoms)	—	33	31	36	x	x	x	x	x	x
21. New‐onset atrial fibrillation	—	37	133	39	x	x	x			x
22. Change in activity and sleep habits	—	20	30	17	x	x				x
23. Discontinuation of multi‐site LV pacing for PNS	—	6	15	16	x	x
24. Twiddler's syndrome	—	27	17	24	x	x			x	x
25. Right ventricular lead dislodgement	—	0	7	18	x	x			x

ACE, angiotensin‐converting enzyme; BNP, brain natriuretic peptide; HF, heart failure; LV, left ventricular; NHR, night heart rate; PNS, phrenic nerve stimulation; RR, median respiratory rate; RSBI, rapid shallow breathing index; S3, third heart sound amplitude; S3/S1, third/first heart sound amplitude ratio; TI, thoracic impedance.

After the first hospitalization, the index remained above the recovery threshold and rose further at the time of the worsening of conditions that led to the second admission. The early warning is calculated starting from the same crossing, while the maximum index is the value reached at the time of the second hospitalization. The index finally recovered after the second discharge.

^aTime between HeartLogic crossing and event.

^bAdmission within 45 days of implantation (before sensor baseline establishment).

^cTime between trigger event and HeartLogic crossing.

^dHF hospitalizations no. 2 and no. 3 occurred consecutively in the same patient.