Table 3.
25‐hydroxyvitamin D, NT‐proBNP, and outcome
| Model | Variable and model | 5 year mortality | First hospitalization | First CV hospitalization | |||
|---|---|---|---|---|---|---|---|
| HR [95% CI] | P‐value | HR [95% CI] | P‐value | HR [95% CI] | P‐value | ||
| 1a | Vitamin D (per 10 ng/mL decrease), unadjusted | 1.55 [1.00; 2.42] | 0.05 | 1.14 [0.90; 1.46] | 0.28 | 1.74 [1.08; 2.80] | 0.023 |
| 1b | Vitamin D (per 10 ng/mL decrease), adjusted for age | 1.16 [0.74; 1.82] | 0.51 | 1.15 [0.90; 1.46] | 0.27 | 1.63 [1.01; 2.64] | 0.046 |
| 1c | Vitamin D (per 10 ng/mL decrease), adjusted for NT‐proBNP | 1.10 [0.70; 1.74] | 0.67 | 1.14 [0.90; 1.46] | 0.28 | 1.62 [1.01; 2.61] | 0.048 |
| 1d | Vitamin D (per 10 ng/mL decrease), adjusted for NT‐proBNP and age | 1.04 [0.66; 1.63] | 0.87 | 1.15 [0.90; 1.46] | 0.27 | 1.59 [0.98; 2.56] | 0.06 |
| 1e | Vitamin D (per 10 ng/mL decrease), adjusted for ¥ | 0.70 [0.33; 1.49] | 0.35 | 1.23 [0.77; 1.97] | 0.38 | 3.60 [1.04; 12.43] | 0.043 |
| 1f | Vitamin D (per 10 ng/mL decrease), adjusted for ¥ and age | 0.68 [0.31; 1.46] | 0.32 | 1.20 [0.75; 1.92] | 0.44 | 3.37 [0.97; 11.74] | 0.06 |
| 2a | NT‐proBNP (per two‐fold increase), unadjusted | 1.72 [1.54; 1.93] | <0.001 | 1.01 [0.93; 1.09] | 0.86 | 1.19 [1.04; 1.36] | 0.013 |
| 2b | NT‐proBNP (per two‐fold increase), adjusted for age | 1.56 [1.37; 1.77] | <0.001 | 1.00 [0.92; 1.10] | 0.93 | 1.14 [0.98; 1.33] | 0.08 |
| 2c | NT‐proBNP (per two‐fold increase), adjusted for Vitamin D | 1.71 [1.53; 1.93] | <0.001 | 1.00 [0.92; 1.08] | 0.98 | 1.16 [1.01; 1.33] | 0.033 |
| 2d | NT‐proBNP (per two‐fold increase), adjusted for Vitamin D and age | 1.56 [1.37; 1.77] | <0.001 | 1.00 [0.92; 1.09] | 1.00 | 1.13 [0.97; 1.31] | 0.12 |
| 2e | NT‐proBNP (per two‐fold increase), adjusted for * | 1.58 [1.20; 2.09] | 0.001 | 1.02 [0.86; 1.21] | 0.79 | 1.12 [0.80; 1.55] | 0.52 |
| 2f | NT‐proBNP (per two‐fold increase), adjusted for * and age | 1.46 [1.11; 1.93] | 0.007 | 0.99 [0.83; 1.18] | 0.90 | 1.06 [0.76; 1.49] | 0.73 |
¥ represents NT‐proBNP, heart failure, diastolic dysfunction by Paulus, atrial fibrillation, oedema, diuretics, vitamin K antagonists or anticoagulants, uric acid, 6 min walk distance, Short Form 36 physical functioning scale, left atrium (end‐systolic), and left atrium volume index. * represents vitamin D, heart failure, diastolic dysfunction by Paulus, atrial fibrillation, oedema, diuretics, vitamin K antagonists or anticoagulants, uric acid, 6 min walk distance, Short Form 36 physical functioning scale, left atrium (end‐systolic), and left atrium volume index. CI, confidence interval; CV, cardiovascular; HR, hazard ratio; NT‐proBNP, N‐terminal pro‐brain natriuretic peptide.