Figure 2.

Relationship between the pathogenesis of polycystic ovary syndrome (PCOS) and steroid hormones and the effective genes in functioning of steroid hormones. Hyperandrogenism causes its adverse effects on follicular development and negative feedback mechanisms. Abbreviation: ER, estrogen receptor; GnRH, gonadotropin releasing hormone; GnRHR, GnRH receptor; GPR147, G protein-coupled receptor 147; IGF, insulin-like growth factor; IN, insulin; INSR, insulin receptor; IRS, insulin receptor substrate; LHCGR, luteinizing hormone/chorionic gonadotropin receptor; PR, progesterone receptor; RFRP-3, arginine-phenylalanine-amide (RFamide)-related peptide 3; SHBG, sex hormone-binding globulin