FIG 3.
Dynamics of blaCTX-M-15 movement between isolates in patient 2. The ISEcp1/blaCTX-M-15 transposition unit (orange) was inserted in the mppA gene in all five isolates from patient 2. (A and B) The initial UTI isolate 2/0 harbored a pEcIMT16316-like plasmid of 135 kbp (light gray) (A), while isolates 2/1, 2/2, and 2/3 all harbored a version of this plasmid with an insertion of 18 kbp of chromosomal genes (dark gray), including the ISEcp1/blaCTX-M-15 transposition unit (B). (C) This region of the plasmid and the flanking genes were deleted in the last isolate 2/4, through homologous recombination between identical flanking transposase genes (IS26 [black]).