TABLE 2.
MICs obtained for lefamulin and comparator agents tested against isolates included in the studya
| Collection no. | Species | MIC (µg/ml) by agent |
||||||
|---|---|---|---|---|---|---|---|---|
| Erythromycin | Clindamycin | Q-D | Linezolid | Lefamulin | Retapamulin | Chloramphenicol | ||
| 975498 | S. aureus | >8 | >64 | 0.5 | 1 | 0.5 (0.5) | ≤0.06 | 16 |
| 981256 | S. aureus | 0.12 | ≤0.5 | 0.5 | 1 | 0.5 (0.5) | 0.5 | 4 |
| 924825 | S. aureus | >8 | ≤0.5 | 0.5 | 1 | 1 (1) | 2 | 8 |
| 953474 | S. aureus | >8 | ≤0.5 | 0.5 | 0.5 | 1 (1) | 1 | 4 |
| 879822 | S. aureus | 0.12 | ≤0.5 | 0.5 | 1 | 2 (>1) | 4 | 8 |
| 913640 | S. aureus | >8 | >64 | 0.5 | 1 | 2 (>1) | 2 | 8 |
| 934242 | S. aureus | 0.12 | ≤0.5 | 0.5 | 0.5 | 2 (1) | 2 | 8 |
| 950457 | S. aureus | 0.12 | 8 | 1 | 1 | 4 (2) | >8 | 4 |
| 916083 | S. aureus | >8 | >64 | 1 | 0.25 | 16 (>1) | 8 | 8 |
| 976441 | S. aureus | >8 | >64 | 4 | 0.5 | 32 (16) | >8 | 64 |
| 972481 | S. aureus | 4 | 4 | 1 | 1 | >32 (>16) | >8 | 4 |
| 939671 | S. cohnii | >8 | ≤0.5 | 1 | 1 | 0.5 (2) | 1 | 4 |
| 939504 | S. epidermidis | >8 | ≤0.5 | ≤0.25 | 16 | 0.5 (1) | 0.25 | 16 |
| 947675 | S. epidermidis | >8 | 16 | ≤0.25 | 0.5 | 1 (0.5) | >8 | 4 |
| 951555 | S. epidermidis | >8 | >64 | 4 | 0.5 | 1 (0.5) | 1 | 4 |
| 955639 | S. epidermidis | 0.12 | ≤0.5 | 0.5 | 0.5 | 1 (1) | 1 | 4 |
| 956923 | S. epidermidis | >8 | 16 | ≤0.25 | 0.25 | 2 (0.5) | >8 | 2 |
| 949426 | S. epidermidis | ≤0.06 | 1 | ≤0.25 | 0.5 | 2 (2) | >8 | 4 |
| 938399 | S. epidermidis | >8 | ≤0.5 | ≤0.25 | 0.5 | 8 (4) | 8 | 2 |
| 952506 | S. epidermidis | >8 | 1 | ≤0.25 | 0.5 | 8 (4) | 8 | 4 |
| 958510 | S. epidermidis | ≤0.06 | 2 | ≤0.25 | 1 | 8 (2) | >8 | 4 |
| 934123 | S. epidermidis | 0.5 | >64 | 1 | 128 | 32 (8) | >8 | 64 |
| 939969 | S. haemolyticus | >8 | >64 | 4 | 2 | 4 (4) | 4 | 32 |
| 944662 | S. sciuri | >8 | >64 | 0.5 | 1 | 16 (8) | 8 | 32 |
| 941213 | S. sciuri | 0.25 | ≤0.5 | 1 | 1 | 32 (>16) | >8 | 4 |
| 960742 | S. lutetiensis | 0.03 | ≤0.5 | 1 | 1 | 0.5 (0.5) | 0.5 | 2 |
| 982012 | S. lutetiensis | ≤0.015 | 1 | 0.5 | 1 | 2 (1) | 2 | 2 |
| 971459 | S. agalactiae | >32 | >64 | 1 | 1 | 8 (8) | 8 | 2 |
| 935557 | S. agalactiae | 0.03 | 4 | 0.5 | 1 | 8 (8) | 4 | 2 |
| 935554 | S. agalactiae | 0.03 | 4 | 0.5 | 0.5 | 16 (16) | 4 | 2 |
| 965031 | S. gallolyticus | >32 | 4 | 1 | 2 | 32 (>16) | >8 | 4 |
a
Values within parentheses are the initial lefamulin MICs obtained during the surveillance studies. Q-D, quinupristin-dalfopristin.