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CYP enzyme inhibition
| Molecule | % inhibitiona |
||||
|---|---|---|---|---|---|
| CYP1A2 | CYP2C8 | CYP2C9 | CYP2D6 | CYP3A4 | |
| 2093 | 4.1 | 87.3 | 13.6 | 36.0 | 25.4 |
| 2114 | 4.0 | 74.7 | –9.20 | 16.6 | 24.9 |
| 2259 | 10.4 | 62.1 | –13.1 | 31.6 | 37.5 |
The values represent the percent inhibition of human CYP isoenzymes obtained with compounds 2093, 2114, and 2259 at 10 μM.
