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hERG inhibition
| Molecule | % inhibitiona |
|||
|---|---|---|---|---|
| –BSA |
+BSA |
|||
| 10 μM | 30 μM | 10 μM | 30 μM | |
| 2093 | 31.6 | 62.1 | 17.9 | 20.9 |
| 2114 | 28.5 | 58.8 | 18.8 | 23.9 |
| 2259 | 23.1 | 64.9 | 12.9 | 19.5 |
The values represent the percent inhibition of the hERG activity for compounds 2093, 2114, and 2259 measured at two concentrations (10 and 30 μM) either without (–) or with (+) bovine serum albumin (BSA).
