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. 2019 Mar 27;63(4):e02492-18. doi: 10.1128/AAC.02492-18

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FIG 4 — Inhibition of organic anion transporting polypeptide 1B1 (OATP1B1) by doravirine. (A) As a positive control, the inhibitory effect of cyclosporine A (CsA; 10 μM) on the uptake of [³H]pitavastatin (0.1 μM) in OATP1B1 stably transfected MDCKII cells was assessed. (B) Inhibitory effect of doravirine on the uptake of [³H]pitavastatin (0.1 μM) in OATP1B1 stably transfected MDCKII cells. (C) Doravirine inhibition of OATP1B1-mediated [³H]pitavastatin (0.1 μM) uptake (percentage of control). All data are means ± SEMs.