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. 2019 Mar 27;63(4):e02112-18. doi: 10.1128/AAC.02112-18

FIG 5.

FIG 5

Active-site superpositions of avibactam-bound VCC-1 with avibactam-bound KPC-2 (A) or CTX-M-15 (B). (A) Superposition of VCC-1 and KPC-2 (PDB accession number 4ZBE) bound to avibactam. VCC-1 carbon atoms are colored gray, with bound avibactam carbon atoms colored green. KPC-2 carbon atoms and bound avibactam carbon atoms are colored orange. The hydrogen-bonding interactions in the VCC-1–avibactam complex are represented as dashed yellow lines, whereas they are orange dashed lines in the KPC-2–avibactam complex. The distances between N-6 and C-7 of avibactam in the VCC-1 and KPC-2 complexes are shown as green and orange dashed lines, respectively. (B) Superposition of VCC-1 and CTX-M-15 (PDB accession number 4S2I) bound to avibactam. VCC-1 carbon atoms are colored gray, with bound avibactam carbon atoms being colored green. CTX-M-15 carbon atoms and bound avibactam carbon atoms are colored magenta. Hydrogen-bonding interactions in the VCC-1–avibactam complex are represented as dashed yellow lines, whereas they are magenta dashed lines in the CTX-M-15–avibactam complex. The distances between N-6 and C-7 of avibactam in the VCC-1 and CTX-M-15 complexes are shown as green and magenta dashed lines, respectively.