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Kinetic parameters of avibactam inhibition of VCC-1 versus KPC-2
| Enzyme | Acylation k2/Ki (M−1 s−1) | Deacylation koff (s−1) | Deacylation t1/2 (min) | Kd (μM) |
|---|---|---|---|---|
| VCC-1 | (3.0 ± 0.5) × 103 | (2 ± 0.1) × 10−3 | 6 ± 1 | 0.686 |
| KPC-2a | (1.3 ± 0.1) × 104 | (1.4 ± 0.1) × 10−4 | 82 ± 6 | 0.011 |
| CTX-M-15a | (1.3 ± 0.1 × 105 | (3 ± 1) × 10−4 | 40 ± 10 | 0.002 |
| P. aeruginosa PAO1 AmpCa | (2.9 ± 0.1) × 103 | (1.9 ± 0.6) × 10−3 | 6 ± 2 | 0.66 |
Kinetic parameters are reproduced from reference 19.
