TABLE 2.
CVVHDF parameters
| Parameter | Data by patient |
|||
|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |
| Dialysate (ml/h) | 1,500 | 1,000 | 550 | 650 |
| Pre-filter replacement (ml/h) | 500 | 450 | 500 | 600 |
| Post-filter replacement (ml/h) | 50 | 50 | 50 | 50 |
| Blood flow (ml/min) | 90 | 40 | 70 | 100 |
| Blood flow (ml/kg/min) | 9 | 6.7 | 13 | 4 |
| Normalized effluent rate (ml/1.73 m2/h) | 8,750 | 8,593 | 6,089 | 3,076 |
| Effluent urea/BUN ratioa | 0.75 | 0.75 | 0.75 | 0.77 |
| Delivered CVVHDF clearance (ml/1.73 m2/h)b | 6,563 | 6,445 | 4,567 | 2,369 |
| Circuit age (h)c | 22.6 | 33.8 | 15.2 | 11.2 |
a
BUN, blood urea nitrogen.
b
Delivered CVVHDF clearance = normalized effluent rate × BUN/effluent urea nitrogen ratio.
c
Measured from circuit change to time of cefepime dose prior to sampling.