TABLE 1.
Plasma pharmacokinetic parameters of bedaquiline and M2 after a single, 160-mg/kg intramuscular injection of long-acting bedaquilinea
| Pharmacokinetic parameter | Values for: |
|
|---|---|---|
| Bedaquiline | M2 | |
| Cmax (ng/ml) | 2,363 (1,447) | 3,002 (1,139) |
| Tmax (h)a | 1–4 | 24–168 |
| AUC0–2,184 (ng·h/ml) | 447,361 (174,979) | 1,689,422 (755,169) |
| AUC0–∞ (ng·h/ml) | 500,850 (201,928) | 1,823,672 (836,740) |
a
A range is given for Tmax values; all other data represent the means (standard deviations) for five mice sampled at each time point.