TABLE 1.

Phenotypic and β-lactamase profiles of the K. pneumoniae, E. coli, and E. cloacae isolates utilized in in vivo efficacy studies

Isolate			MIC (μg/ml) for:
Identification	Bacterial species	β-Lactamase(s) encoded	Meropenem	Nacubactam	Meropenem-nacubactama
EC 548b	E. coli	KPC-3, TEM-1	8	2	0.5
KP 652b	K. pneumoniae	KPC-3	64	>256	1
ECL 72	E. cloacae	AmpC, KPC-3, TEM-1	32	>256	1
KP 651b	K. pneumoniae	KPC-2	64	>256	2
KP 599c	K. pneumoniae	KPC-2, SHV-11	>64	64	2
KP 604c	K. pneumoniae	KPC-3, TEM-1, SHV-11	>64	2	2
KP C4-10	K. pneumoniae	CTX-M-15, SHV-11, TEM-1, OXA-9, KPC-3	>64	>256	2
KP C8-9	K. pneumoniae	SHV-12, TEM-1, KPC-2	>64	>256	2
ECL 119b	E. cloacae	NMC-A	32	128	2
KP C30-27	K. pneumoniae	SHV-11, TEM-1, KPC-2	>64	>256	4
ECL 118b	E. cloacae	NMC-A	64	>256	4
KP 648b	K. pneumoniae	KPC-3	>64	>256	4

^aMeropenem/nacubactam concentration ratio of 1:1.

^bClinical isolates obtained from FDA-CDC Antimicrobial Resistance Isolate Bank (Atlanta, GA).

^cClinical isolates obtained from F. Hoffmann-La Roche Ltd. (Basel, Switzerland).