Table 1.
Characteristics of 220 Patients with Medullary Thyroid Carcinoma in Denmark, 1997–2014
| Hereditary | ||||
|---|---|---|---|---|
| All | Sporadic | By symptoms | By screening | |
| Characteristics | (n = 220) | (n = 167) | (n = 10) | (n = 43) |
| At diagnosis | ||||
| Sex, n (%) | ||||
| Female | 131 (60) | 105 (63) | 7 (70) | 19 (44) |
| Male | 89 (40) | 62 (37) | 3 (30) | 24 (56) |
| Age (years), median (IQR) | 53 (39–66) | 57 (45–69) | 36 (18–59) | 37 (22–48) |
| MEN2 syndrome, n (%) | ||||
| MEN2A | 46 (87) | 7 (70) | 39 (91) | |
| MEN2B | 7 (13) | 3 (30) | 4(9) | |
| Thyroid surgery, n (%) | ||||
| No thyroid surgery | 12 (5) | 11 (7) | 0 | 1 (2) |
| Diagnostic open biopsy | 5 (2) | 5 (3) | 0 | 0 |
| Hemithyroidectomy | 3 (1) | 3 (2) | 0 | 0 |
| Total thyroidectomy | 200 (91) | 148 (89) | 10 (100) | 42 (98) |
| Lymph node surgery, n (%) | ||||
| No lymph node surgery | 39 (18) | 28 (17) | 2 (20) | 9 (21) |
| Lymph node extirpation | 39 (18) | 31 (19) | 0 | 8 (19) |
| Modified neck dissection | 125 (57) | 93 (56) | 6 (60) | 26 (60) |
| Classic neck dissection | 17 (8) | 15 (9) | 2 (20) | 0 |
| T category, n (%) | ||||
| T0 | 1 (0) | 1 (1) | 0 | 0 |
| T1 | 91 (41) | 49 (29) | 5 (50) | 37 (86) |
| T2 | 57 (26) | 53 (32) | 1 (10) | 3 (7) |
| T3 | 27 (12) | 23 (14) | 2 (20) | 2 (5) |
| T4 | 42 (19) | 39 (23) | 2 (20) | 1 (2) |
| Tx | 2 (1) | 2 (1) | 0 | 0 |
| N category, n (%) | ||||
| N0 | 103 (47) | 75 (45) | 2 (20) | 26 (60) |
| N1 | 117 (53) | 92 (55) | 8 (80) | 17 (40) |
| M category, n (%) | ||||
| M0 | 199 (90) | 146 (87) | 10 (100) | 43 (100) |
| M1 | 21 (10) | 21 (13) | 0 | 0 |
| TNM stage,an (%) | ||||
| I | 56 (25) | 31 (19) | 1 (10) | 24 (56) |
| II | 40 (18) | 37 (22) | 1 (10) | 2 (5) |
| III | 17 (8) | 10 (6) | 1 (10) | 6 (14) |
| IV | 106 (48) | 88 (53) | 7 (70) | 11 (26) |
| Unknown | 1 (0) | 1 (1) | 0 | 0 |
Due to rounding up, not all sums of percentages fit.
a
Staging was based on the American Joint Committee on Cancer seventh and eighth editions (29,30).
IQR, interquartile range; MEN2, multiple endocrine neoplasia 2; T, tumor; N, node; M, metastasis.