Table 3.

Disease-Specific Survival and Prognostic Factors in Patients with Medullary Thyroid Carcinoma in Denmark, 1997–2014

	Disease-specific survival, % (n = 220)				Univariate (n = 220)			Multivariate (n = 217)
Factors	5-year	10-year	15-year	20-year	HR	[CI]	p-Value	HR	[CI]	p-Value
Sex
Female	87	83	83	79	1			1
Male	73	61	54	54	2.6	[1.5–4.5]	0.001	2.4	[1.3–4.4)	0.005
Age at diagnosis (years)
<21	93	93	93		1			1
21–40	93	87	87	87	1.6	[0.2–13.3]	0.686	0.6	[0.1–7.1]	0.711
41–60	85	80	71	64	3.5	[0.5–26.3]	0.224	1.1	[0.1–11.0]	0.963
>60	67	54	54		8.7	[1.2–64.5]	0.034	2.8	[0.3–29.4]	0.380
MTC type
HMTC, by screening	100	96	96	96	1			1
HMTC, by symptoms	77	77	77		8.8	[0.8–97.1]	0.076	5.3	[0.5–61.3]	0.182
SMTC	77	69	64		15.9	[2.2–115.5]	0.006	4.9	[0.6–42.9]	0.148
T categorya
T1	93	91	91	91	1			1
T2	86	78	68	58	3.3	[1.3–8.2]	0.009	2.1	[0.8–5.5]	0.129
T3	71	64	64		4.7	[1.7–12.9]	0.003	2.3	[0.8–6.7]	0.115
T4	57	43	43		10.4	[4.4–24.4]	<0.001	2.9	[1.2–7.2]	0.022
N category
N0	95	93	91	87	1			1
N1	70	58	54	54	6.1	[2.9–13.0]	<0.001	2.7	[1.1–6.4]	0.025
M category
M0	89	82	79	76	1			1
M1	14				20.4	[10.8–38.5]	<0.001	12.3	[6.0–25.0]	<0.001d
TNM stageb
I	98	98	98	98	1
II	97	93	87	78	5.4	[0.6–48.3]	0.132
III	94	87	87	87	6.9	[0.6–76.6]	0.114
IV	64	53	49		31.8	[4.4–231.4]	0.001
Multifocalityc
No	91	82	77		1
Yes	83	78	78	78	1.2	[0.6–2.4]	0.636
Bilateralityc
Yes	86	79	79	79	1
No	89	81	76		1.1	[0.5–2.3]	0.889

^aBased on 217 patients with pertinent data.

^bBased on 219 patients with pertinent data. Staging was based on the American Joint Committee on Cancer seventh and eighth editions (29,30).

^cBased on 200 patients, who underwent total thyroidectomy.

^dSignificant after Bonferroni correction (31).