Table 4.
Characteristics of 194 Patients Evaluated for Long-Term Biochemical Curea Following Diagnosis of Medullary Thyroid Carcinoma in Denmark, 1997–2014
| Characteristics | Cured | Not cured |
|---|---|---|
| (n = 70) | (n = 124) | |
| At diagnosis | ||
| Sex, n (%) | ||
| Female | 49 (70) | 69 (56) |
| Male | 21 (30) | 55 (44) |
| Age (years), median (IQR) | 46 (35–57) | 54 (40–66) |
| MEN2 syndrome, n (%) | ||
| MEN2A | 17 (89) | 27 (84) |
| MEN2B | 2 (11) | 5 (16) |
| MTC type, n (%) | ||
| HMTC, by screening | 18 (26) | 23 (19) |
| HMTC, by symptoms | 1 (1) | 9 (7) |
| SMTC | 51 (73) | 92 (74) |
| Thyroid surgery, n (%) | ||
| Total thyroidectomy | 70 (100) | 124 (100) |
| Lymph node surgery, n (%) | ||
| No lymph node surgery | 15 (21) | 12 (10) |
| Lymph node extirpation | 17 (24) | 14 (11) |
| Modified neck dissection | 38 (54) | 81 (65) |
| Classic neck dissection | 0 | 17 (14) |
| T category, n (%) | ||
| T0 | 0 | 1 (1) |
| T1 | 45 (64) | 40 (32) |
| T2 | 16 (23) | 35 (28) |
| T3 | 7 (10) | 17 (14) |
| T4 | 1 (1) | 31 (25) |
| Tx | 1 (1) | 0 |
| N category, n (%) | ||
| N0 | 65 (93) | 29 (23) |
| N1 | 5 (7) | 95 (77) |
| M category, n (%) | ||
| M0 | 70 (100) | 116 (94) |
| M1 | 0 | 8 (6) |
| TNM stage,bn (%) | ||
| I | 43 (61) | 10 (8) |
| II | 20 (29) | 18 (15) |
| III | 3 (4) | 13 (10) |
| IV | 3 (4) | 83 (67) |
| Unknown | 1 (1) | 0 |
Due to rounding up, not all sums of percentages fit.
a
Long-term biochemical cure was defined as undetectable basal serum calcitonin at last biochemical follow-up in patients who had received no other treatment besides initial surgery.
b
Staging was based on the American Joint Committee on Cancer seventh and eighth editions (29,30).