Table 5.

Analysis of Prognostic Factors for Long-Term Biochemical Cure^a in Patients who had Undergone Total Thyroidectomy for Medullary Thyroid Carcinoma in Denmark, 1997–2014

	Univariate (n = 194)			Multivariate (n = 192)
Factors	OR	[CI]	p-Value	OR	[CI]	p-Value
Sex
Female	1.9	[0.999–3.5]	0.051	1.1	[0.4–2.9]	0.867
Male	1			1
Age at diagnosis (years)
<21	1.7	[0.5–6.1]	0.381	5.8	[0.6–53.1]	0.120
21–40	2.9	[1.3–6.6]	0.013	2.5	[0.6–10.3]	0.197
41–60	1.9	[0.9–4.1]	0.087	1.1	[0.4–3.3]	0.844
>60	1			1
MTC type
HMTC, by screening	7.0	[0.8–60.8]	0.076	2.1	[0.1–38.0]	0.696
HMTC, by symptoms	1			1
SMTC	5.0	[0.6–40.5]	0.133	3.4	[0.1–86.6]	0.454
T categoryb
T1	34.9	[4.6–267.2]	0.001	11.3	[0.96–131.6]	0.054
T2	14.2	[1.8–113.1]	0.012	2.4	[0.2–27.0]	0.479
T3	12.8	[1.4–112.6]	0.022	4.0	[0.3–54.1]	0.291
T4	1			1
N category
N0	42.6	[15.7–115.8]	<0.001	40.1	[12.0–133.7]	<0.001e
N1	1			1
M categoryc
M0
M1
TNM staged
I	118.97	[31.1–455.1]	<0.001
II	30.7	[8.2–114.6]	<0.001
III	6.4	[1.2–35.1]	0.033
IV	1
Multifocality
No	3.7	[1.8–7.6]	<0.001	5.0	[1.2–20.1]	0.024
Yes	1
Bilaterality
Yes	1
No	1.8	[0.9–3.7]	0.110

^aLong-term biochemical cure was defined as undetectable basal serum calcitonin at last biochemical follow-up in patients who had received no other treatment besides initial surgery.

^bBased on 192 patients with pertinent data.

^cAnalyses could not be performed as no patients with distant metastases were biochemically cured.

^dBased on 193 patients with pertinent data. Staging was based on the American Joint Committee on Cancer 7th and 8th edition (29,30).

^eSignificant after Bonferroni correction (31).

OR, odds ratio.