Table 1.
Composition of triglycerides in isolated hepatic lipid droplets from mutant knock-in (MUT) and wild-type (WT) mice measured by lipidomic analyses.
| MUT |
WT |
|||||
|---|---|---|---|---|---|---|
| CTR | ASO | P value | CTR | ASO | P value | |
| MUFA | 63 (0.47) | 58 (0.43) | 6.1 × 10−5 | 64 (0.39) | 57 (0.58) | 7.6 × 10−6 |
| 16:1 | 10 (0.22) | 7 (0.35) | 2.4 × 10−4 | 11 (0.17) | 7 (0.13) | 1.0 × 10−9 |
| 18:1 | 53 (0.46) | 52 (0.21) | 0.034 | 54 (0.52) | 51 (0.53) | 0.001 |
| PUFA | 14 (0.29) | 17 (0.50) | 1.1 × 10−5 | 12 (0.38) | 17 (0.48) | 1.3 × 10−6 |
| 18:2 | 11 (0.42) | 13 (0.48) | 0.007 | 11 (0.35) | 13 (0.49) | 0.006 |
| 20:3 | 0.78 (0.03) | 1.08 (0.05) | 1.3 × 10−4 | 0.53 (0.04) | 1.01 (0.03) | 3.3 × 10−5 |
| 20:4 | 0.68 (0.02) | 1.04 (0.03) | 2.6 × 10−7 | 0.31 (0.02) | 1.09 (0.03) | 1.2 × 10−7 |
| 22:5 | 0.32 (0.05) | 0.95 (0.05) | 2.6 × 10−5 | 0.07 (0.01) | 0.90 (0.03) | 9.1 × 10−9 |
| 22:6 | 0.74 (0.17) | 1.06 (0.09) | 0.048 | 0.17 (0.01) | 0.96 (0.03) | 1.4 × 10−9 |
| SFA | 24 (0.39) | 25 (0.57) | 0.999 | 24 (0.72) | 26 (0.63) | 0.141 |
| 14:0 | 0.47 (0.04) | 0.41 (0.03) | 0.275 | 0.46 (0.02) | 0.40 (0.03) | 0.122 |
| 16:0 | 22 (0.38) | 22 (0.51) | 0.693 | 22 (0.67) | 24 (0.59) | 0.093 |
| 18:0 | 1.3 (0.03) | 1.8 (0.08) | 4 × 10−4 | 1.2 (0.06) | 1.8 (0.06) | 9 × 10−5 |
Data are presented as mean (SEM). P values are calculated by t test and adjusted for multiple testing by Bonferroni. Individuals fatty acids are denoted as number of carbon and of double bonds.
Abbreviations: MUFA: Monounsaturated fatty acid; PUFA: Polyunsaturated fatty acid; SFA: Saturated fatty acid.