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. 2019 Feb 5;22:96–109. doi: 10.1016/j.molmet.2019.01.012

Figure 1.

Figure 1

Synbiotic intervention significantly reversed HFD-induced weight gain and associated metabolic syndrome parameters after 12 weeks of intervention. (a) Body weight gain as the percentage of baseline weight for each mouse. (b) Fasting blood glucose. (c) Fasting insulin. (d) HOMA-IR, calculated by fasting blood glucose (mmol/L) x fasting insulin (mU/L)/22.5. (e) Curve of normalized OGTT (Oral glucose tolerance tests). Data are normalized by subtracting the baseline value (fasting blood glucose) from the measured value in each mouse. (f) Areas under the curve (AUC) of normalized OGTT. The original Curve of OGTT and AUC of OGTT are available in the Supplementary Figures S12 and S13. (g-i) Levels of LBP (g), cholesterol (h) and triglycerides (i) in serum. Hematoxylin and eosin-stained sections of the liver (j) and epididymal adipose tissue (eAT) (k). Data are shown as means ± SEM. Groups with different letters are significantly different from each other as assessed by one-way ANOVA followed by Tukey post hoc test (P < 0.05). n = 12 or n = 8 (for g-k) mice per group.