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. 2019 Feb 8;22:71–83. doi: 10.1016/j.molmet.2019.02.001

Figure 2.

Figure 2

Pex5 ablation in β-cells causes impaired glucose homeostasis in mice. (A, D) Body weights, (B, E) fed state blood glucose levels, and (C, F) fasting blood glucose levels of tamoxifen-treated control and Rip-Pex5−/− mice supplemented with either normal chow or HFD for 12 weeks (n = 13–16 per group). (G, H) Blood glucose and AUC measurements of IPGTT performed in control and Rip-Pex5−/− mice supplemented with either normal chow or HFD for 12 weeks (n = 13–16 per group). Data are expressed as mean ± SEM. p < 0.01: **; p < 0.001: *** Rip-Pex5−/− versus respective control mice. p < 0.001: † HFD-fed control and Rip-Pex5−/− mice versus chow-fed control and Rip-Pex5−/− mice, respectively.