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. 2019 Feb 8;22:71–83. doi: 10.1016/j.molmet.2019.02.001

Figure 3.

Figure 3

Glucose-stimulated insulin secretion is impaired in Rip-Pex5−/−mice. (A, B) Plasma insulin levels in response to a glucose bolus in control and Rip-Pex5−/− mice supplemented with either chow (n = 4) or HFD (n = 5). (C, D) Insulin secretion in response to glucose was measured ex vivo using islets from control and Rip-Pex5−/− mice supplemented with either normal chow or HFD for 12 weeks (n = 4–5 per group; 50 islets per mouse). Data are presented both as % insulin released from total content and as stimulation index. (E) Pancreatic insulin content measurements in both chow and HFD-fed control and Rip-Pex5−/− mice (n = 5). (F) β-cell mass of chow and HFD-fed control and Rip-Pex5−/− mice (n = 4 per group). (G) Pancreatic islet size measurements of HFD-fed control and Rip-Pex5−/− mice (n = 9 per group; 15–25 islets per mouse). All values are expressed as mean ± SEM. p < 0.05: †; p < 0.001: ††† HFD-fed control versus chow-fed controls. p < 0.05: *; p < 0.01: **; p < 0.001: *** Rip-Pex5−/− versus respective control mice.