Figure 6.

Expression of LAMP2 in β-cells of Rip-Pex5^−/−mice. Representative islet sections of (A) control and (B)Rip-Pex5^−/− mice stained for LAMP2 (green) and insulin (red). Scale bars, 100 μm. In the enlargement and in the fluorescence intensity plots, it is shown that strong LAMP2 staining in Pex5^−/− islets occurs in cells containing low levels of insulin. (C) Quantification of mean intensity of LAMP2 in control and Rip-Pex5^−/− mice (n = 3 per genotype; 12–16 islets per mouse). Data are expressed as mean ± SEM. p < 0.001: ***; Rip-Pex5^−/− versus control mice. a.u., arbitrary units.