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. 2019 Mar 20;25:2079–2086. doi: 10.12659/MSM.915541

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© Med Sci Monit, 2019

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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Knockdown of SNHG16 inhibits proliferation, migration, and invasion and reverses sorafenib resistance in HCC cells. (A) Hep3B and HepG2 cells were transfected with SNHG16 siRNA or a scrambled negative control. The transfection efficiency was detected by qRT-PCR. ** P<0.01. (B) Hep3B and HepG2 cells were transfected with SNHG16 siRNA or a scrambled negative control. Cell growth was detected at days 1–3 after transfection. The data are presented as the mean ±SD. ** P<0.01. (C) HepG2 cells were transfected with SNHG16 siRNA or a scrambled negative control. Cell migration and invasion abilities were analysed by Transwell migration assay (above) and invasion assay (below) (magnification: ×200). ** P<0.01. (D) Hep3B and HepG2 cells were transfected with SNHG16 siRNA or a scrambled negative control. The sensitivity to sorafenib was detected by CCK-8 assay.