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Effects of AO-1 on mRNA expression in EAE mice. (a), (c) Spinal cord. (b), (d) Cerebral cortex. On Day 21 after MOG35–55 immunization, the spinal cords and cerebral cortices of untreated vehicle and AO-1-treated mice were harvested and the mRNAs expression levels were analyzed through qPCR. Date are expressed as mean ± SEM (n = 4). ∗ P < 0.05 and ∗∗∗ P < 0.001 compared with vehicle group.
