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. 2019 Mar 21;10:165. doi: 10.3389/fendo.2019.00165

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Copyright © 2019 Vogtmann, Kühnel, Dicke, Verkaik-Schakel, Plösch, Schorle, Stojanovska, Herse, Köninger, Kimmig, Winterhager and Gellhaus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Morphometric analysis of placentas in the hsFLT1/rtTA mouse model. Analysis of the labyrinthine (A), spongiotrophoblast (B), and total placental area (C) as well as labyrinth to spongiotrophoblast area ratio (D) of human soluble fms-like tyrosine kinase 1 (hsFLT1) expressing fetal growth restriction wild-type placentas (FGR wt; n = 8), compared to control (n = 8), and doxycycline (Dox) control (n = 7) placentas. FGR wt placentas showed slight reduction in labyrinth and total placental area and labyrinth to spongiotrophoblast ratio compared to both control groups, whereas spongiotrophoblast area was slightly increased. Data is presented in box and whisker plot. *p < 0.05 as determined by the Kruskal–Wallis test with Dunn's post hoc test.