Table 2.
Patient | A | B | C | D | E | F |
---|---|---|---|---|---|---|
Reason for CMV testing | Failed hearing screen | Failed hearing screen | Failed hearing screen | Mother with prenatal CMV infection | Ventriculomegaly on prenatal US | Twin of newborn E |
Sex | Female | Female | Female | Female | Male | Female |
Race/ethnicity | White/Non-Hispanic | Black/Non-Hispanic | White/Non-Hispanic | Other/Hispanic | White/Non-Hispanic | White/Non-Hispanic |
Delivery | Vaginal | Vaginal | Vaginal | Vaginal | Cesarean | Vaginal |
Gestational age (weeks, days) | 39, 6 | 40, 1 | 39, 0 | 40, 5 | 38, 4 | 38, 4 |
BW (%)a | 3.2 | 97.2 | 4.9 | 92.4 | 1.3 | 0.6 |
Head circumference (%)a | 2.2 | 63.6 | 0.2 | 54.1 | 12.8 | 40.3 |
Newborn hearing screen result | Unilateral fail | Unilateral fail | Unilateral fail | Normal | Bilateral fail | Normal |
Confirmatory audiology test result | Bilateral hearing loss | Normal | Normal | Unknownb | Bilateral hearing loss | Normal |
CMV test results | Saliva+, urine+ | Saliva+, urine−c | Saliva+, urine+ at 10 weeks | Saliva+, urine+ | Saliva not tested, urine+ |
Saliva not tested, urine+ |
Additional workup | Bilateral subependymal cysts | None | None | Normal | Thrombocytopenia | Thrombocytopenia, choroid plexus cysts |
Treatment with valganciclovir | Yes | No | No | No | Yes | Yes |
Abbreviations: +, positive; −, negative; BW, birth weight; CMV, cytomegalovirus; US, ultrasound.
aFor birth weight and head circumference percentiles, the WHO growth curves were used if gestational age was ≥37 weeks, and the Fenton growth curves were used if gestational age was <37 weeks.
bResults of outpatient audiology evaluation were not documented for this patient.
cThe saliva polymerase chain reaction (PCR) assay result was weakly positive, and the urine PCR assay result was negative.