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. 2019 Mar 28;20:248. doi: 10.1186/s12864-019-5611-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — DNA methylation patterns in distal and promoter peaks. a Bar plot for proportion of peaks that overlap with hypomethylated regions in each stage. b Violin plot demonstrates the differences between distal and promoter peaks in each stage for H3K4me3 and H3K27me3. c Violin plot showing the DNA methylation pattern dynamics in hypermethylated promoter peaks found in 16-cell and 128-cell stages for H3K4me3 and H3K27me3. d Histone modification dynamics for hypermethylated promoter peak-associated genes found in the 16-cell and 128-cell stages. Note: ‘***’ denotes that there is a significant difference detected by the Wilcox test