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. 2019 Mar 28;38:137. doi: 10.1186/s13046-019-1138-7

Table 2.

Univariate and Multivariate Analyses of Factors Associated With survival and recurrence

Overall survival Cumulative recurrence
Multivariate Analysis Multivariate Analysis
Variable Univariate P HR 95%CI P* Univariate P HR 95%CI P
Age, year (≥60 vs. <60) 0.230 NA 0.286 NA
Gender (Men vs. Women) 0.741 NA 0.798 NA
Anatomic site (Acra vs. Trunk vs. Other) 0.858 NA 0.887 NA
Histologic type (Superfical spreading vs. Nodular vs. Acral vs. Lentigo maligna) 0.089 NA 0.054 NA
Ulceration (Present vs. Absent) 0.284 NA 0.249 NA
Breslow depth (mm) (≤2 vs. > 2) 0.014 1.839 1.347–2.916 0.037 0.024 1.526 1.135–2.527 0.046
Clark level (I-III vs. IV-V) 0.023 NS 0.031 NS
Lymph nodes metastasis (Yes vs. No) 0.015 NS 0.015 NS
Distant metastasis (Yes vs. No) 0.002 NS 0.003 NS
Clinical stage (Yes vs. No) 0.004 3.853 2.325–6.518 0.001 < 0.001 4.104 2.395–6.718 < 0.001
TRIM44 staining (Low vs. High) 0.010 1.297 1.040–2.215 0.019 0.005 1.230 1.012–2.010 0.004

Note: OS overall survival, DFS disease free survival, NS not significant, NA not adopt

*, p < 0.05 was regarded as statistically significant, p value was calculated using Cox proportional hazards regression