Table 3.
Sensitivity, specificity, PPV and NPV of the different tests
| Test | Endpoint | Sensitivity | Specificity | PPV | NPV | Youden |
|---|---|---|---|---|---|---|
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | |||
| HPV DNA | CIN2+ | 98.2% (90.2, 99.7) | 17.5% (13.2, 22.7) | 20.7% (16.2, 26.1) | 97.7% (88.2, 99.6) | 15.7 |
| CIN3+ | 100% (86.7, 100) | 16.0% (12.1, 20.8) | 9.8% (6.7, 14.0) | 100% (92.0, 100) | 16.0 | |
| HPV E6/E7 mRNA | CIN2+ | 87.0% (75.6, 93.6) | 42.7% (36.7, 48.9) | 25.0% (19.4, 31.7) | 93.8% (87.7, 96.9) | 29.7 |
| CIN3+ | 88.0% (70.0, 95.8) | 39.6% (34.0, 45.5) | 11.7% (7.9, 17.1) | 97.3% (92.4, 99.1) | 27.6 | |
| p16/Ki67 | CIN2+ | 98.2% (90.2, 99.7) | 82.5% (77.3, 86.8) | 55.2% (45.3, 64.8) | 99.5% (97.3, 99.9) | 80.7 |
| CIN3+ | 100% (86.7, 100) | 74.2% (68.7, 79.0) | 26.0% (18.3, 35.6) | 100% (98.2, 100) | 74.2 |
Note: PPV = positive predictive value; NPV = negative predictive value. Results in % with 95% confidence interval (95% CI)