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SM reduces the expression of LPA1 and ATX in ankle tissues. Immunohistochemical staining acquired from ankle joints of the several groups (a) with LPA1 detection and (b) ATX detection. OD measurements of LPA1 (c) and ATX (d) were analysed. Values are the mean ± SEM (n = 6). #P< 0.05, ##P< 0.01 compared with the control group. ∗P< 0.05, ∗∗P< 0.01 compared with the CIA group.
