Table 1.
Group | D8 | D9 | D10 | D14 | D28 | |
---|---|---|---|---|---|---|
UPE (mg/d) | Ctr | 1.47 ± 0.11 | 1.43 ± 0.18 | 1.45 ± 0.16 | 1.43 ± 0.14 | 1.46 ± 0.21 |
Sham | 1.42 ± 0.18 | 1.49 ± 0.16 | 1.40 ± 0.15 | 1.42 ± 0.15 | 1.48 ± 0.20 | |
AKI 20 | 1.43 ± 0.15 | 1.53 ± 0.24 | 1.48 ± 0.17 | 1.50 ± 0.12 | 1.52 ± 0.15 | |
AKI 30 | 1.46 ± 0.13 | 1.86 ± 0.38 | 1.97 ± 0.22 | 3.64 ± 1.12* | 10.88 ± 2.44** | |
AKI 40 | 1.38 ± 0.20 | 3.47 ± 0.63* | 2.52 ± 0.26* | 1.54 ± 0.33 | 1.55 ± 0.18 | |
BUN (mmol/L) | Ctr | 11.41 ± 1.22 | 12.28 ± 1.01 | 10.99 ± 0.43 | 12.37 ± 1.29 | 10.93 ± 1.20 |
Sham | 12.07 ± 1.31 | 10.92 ± 1.26 | 11.74 ± 0.55 | 12.49 ± 1.31 | 11.56 ± 1.47 | |
AKI 20 | 11.89 ± 1.36 | 27.30 ± 2.32* | 15.13 ± 1.11* | 12.20 ± 1.24 | 11.12 ± 1.13 | |
AKI 30 | 10.84 ± 1.47 | 28.48 ± 2.01* | 17.36 ± 1.32* | 25.45 ± 2.99*# | 28.77 ± 1.23*# | |
AKI 40 | 12.35 ± 1.41 | 30.19 ± 2.62*# | 25.27 ± 2.53*# | 28.66 ± 1.78*# | 37.48 ± 2.15*#Δ | |
Scr (umol/L) | Ctr | 7.41 ± 0.82 | 7.20 ± 0.81 | 6.91 ± 0.63 | 7.03 ± 0.72 | 6.89 ± 0.75 |
Sham | 7.03 ± 0.71 | 7.19 ± 0.98 | 7.17 ± 0.81 | 6.99 ± 0.76 | 7.11 ± 0.87 | |
AKI 20 | 7.12 ± 0.80 | 16.39 ± 1.84* | 13.88 ± 1.21* | 7.78 ± 1.26 | 7.35 ± 1.18 | |
AKI 30 | 7.81 ± 0.67 | 16.72 ± 1.56* | 12.96 ± 1.43* | 15.26 ± 1.29*# | 22.34 ± 1.17*# | |
AKI 40 | 7.39 ± 0.88 | 16.58 ± 2.07*# | 23.22 ± 2.38*# | 28.97 ± 2.92*#Δ | 28.04 ± 1.09*#Δ |
UPE, urinary protein excretion; BUN, blood urea nitrogen; Scr, serum creatinine. *P < 0.05 vs Ctr, **P < 0.01 vs Ctr, #P < 0.05 vs AKI 20, ΔP < 0.05 vs AKI 30