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. 2019 Mar 27;11:54. doi: 10.1186/s13148-019-0651-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Pathway analysis of candidate genes significantly altered by TET2-knockout. Selected, significant pathway enrichment annotations from GREAT for genes exhibiting significantly altered expression in both TET2-knockout cell lines and in tumor versus normal samples from the TCGA (binomial p value < 0.05). Bar coloration indicates the number of candidate genes enriched within each pathway